Effects of Liraglutide on plasma fibroblast growth factor-21 level in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1674-6090.2011.01.016
- VernacularTitle:利拉鲁肽对2型糖尿病人血浆FGF-21水平的影响
- Author:
Peiyu WU
;
Gangyi YANG
;
Ling LI
- Publication Type:Journal Article
- Keywords:
Liraglutide;
Fibroblast growth factor-21;
Type 2 diabetes mellitus
- From:
Journal of Endocrine Surgery
2011;05(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Liraglutide on plasma FGF-21 level in patients with type 2 diabetes mellitus (T2DM). Methods Enzyme linked immunosorbent assay (ELISA) was used to measure plasma FGF-21 level in patients with T2DM and normal controls (NGT). Relationship between plasma FGF-21level and BMI, WHR, HOMA-IR, HOMA-IS, FFA was analyzed. After Liraglutide treatment, plasma FGF-21level was observed in patients with T2DM. Results Fasting plasma FGF-21 level was higher in T2DM patients than that in normal control group ( 1.81 ±0.32 vs. 1.32 ±0.09 μg/L, P ＜0.01 ). After Liraglutide treatment, WHR, BMI, FPG, 2hPBG, HbA1c and FFA in T2DM patients significantly decreased ( P ＜0.05 or P ＜0. 01 ),HOMA-IS remarkably increased (P ＜ 0. 01 ), and FGF-21 had no change. Conclusion Liraglutide and FGF-21may have different roles in insulin resistance.
