Effects of hyperthyroidism on glucose metabolism and its clinical significance
10.3760/cma.j.issn.1674-6090.2014.01.014
- VernacularTitle:甲状腺功能亢进症对糖代谢影响及临床意义
- Author:
Bihui ZHANG
- Publication Type:Journal Article
- Keywords:
Hyperthyroidism;
Abnormal glucose metabolism;
Pancreatic β-cell function
- From:
Journal of Endocrine Surgery
2014;8(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand effects of hyperthyroidism on glucose metabolism and its clinical significance.Methods 65 patients admitted in Xixi Street Community Health Center were divided into 3 groups according to their accompanying disease:group A,22 cases of hyperthyroidism accompanying with diabetes mellitus,group B,23 cases of diabetes,and group C,20 cases of hyperthyroidism.Group A and B were treated with intensive insulin therapy.Group B patients took oral methimazole or propylthiouracil.Group C patients were treated with conventional treatment of hyperthyroidism.All patients were treated for three weeks.Fasting plasma glucose (FPG) and postprandial 2h plasma glucose (2hBG),heart rate,serum triiodothyronine three (TT3),serum total thyroxine (TT4)and other indicators were recorded before and after treatment.Results After intensive insulin therapy,FPG and 2h BG of patients in group A and B were controlled in ideal range.After treatment,TT3 and TT4 decreased significantly faster than before treatment(P ＜ 0.05).Patients in group A needed more insulin than in group B to bring the blood glucose to the normal level(P ＜0.05),but after three weeks,patients in group A and group B needed similar dose of insulin.Patients in group A needed more time than patients in group B to bring down the blood glucose level.(P ＜ 0.05).In addition,change of heart rate in group A before and after treatment were greater than the other two groups,and patients' heart rate in group A returned to normal after three weeks of treatment.(P ＜ 0.05).Conclusions Thyroid hormones affects glucose metabolism.Diabetes complicated with hyperthyroidism mainly caused by patient's abnormal glucose metabolism and insulin resistance.Intensive insulin therapy for these patients can improve β cell function,lower blood glucose rapidly.Compared with diabetes patient without complication of hyperthyroidism,early intensive insulin therapy should be considered.
