Meta-analysis of CTLA-4 promoter-49 A/G polymorphism and Graves' disease in China

VernacularTitle:CTLA-4基因49位点多态性与中国人Graves病相关性的Meta分析
Author: Yaodong ZHANG ; Lina TAN ; Haiyan WEI ; Shuying LUO ; Yongxing CHEN
Publication Type:Journal Article
Keywords: Meta-analysis; Cytotoxic T lymphocyte associated antigen-4; Graves' disease; Gene polymorphisms
From:Journal of Endocrine Surgery 2013;7(1):64-68
CountryChina
Language:Chinese
Abstract: Objective To summarize the correlation between cytotoxic T lymphocyte associated antigen-4 (CTLA-4) promoter-49 A/G polymorphism and Graves' disease (GD)in China.Methods The publications before Sep.30,2011 about the correlation between CTLA-4 promoter-49 A/G polymorphism and GD in China were collected by searching CNKI,CBM,and Wanfang database.Meta-analysis was performed to check the difference of genotypes such as AG,GG,GG + AG,and G allele between GD group and the control group.Results A total of 6 studies involving 570 cases in GD group and 486 cases in the control group were included in the meta-analysis.According to the heterogeneity of these studies,meta-analysis was performed to analyze the correlation between AG,GG,GG + AG genotype,G allele and GD by fixed effects model.The pooled OR value(95％ CI) of various studies was 1.97 (1.37-2.82),3.66 (2.42-5.53),2.55 (1.82-3.58),and 1.99 (1.49-2.65).Conclusion The meta-analysis demonstrates that CTLA-4 promoter-49 A/G polymorphism increases the possibility of getting GD in Chinese.