Analysis of prognosis-related factors of local-regional recurrence breast cancer
10.3760/cma.j.issn.1674-6090.2015.01.014
- VernacularTitle:局部区域复发乳腺癌预后的相关因素分析
- Author:
Jiajia GUO
;
Fuzhong TONG
;
Yingming CAO
;
Peng LIU
;
Yuan PENG
;
Shu WANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasm;
Neoplasm recurrence;
Local;
Prognosis
- From:
Journal of Endocrine Surgery
2015;9(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prognostic factors and their influences on breast cancer patients with local-regional recurrence.Methods From Jan.1st,1998 to Dec.30th,2007,66 breast cancer patients with local-regional recurrence were treated at Breast Center of Peking University People's Hospital.The overall survival of the patients was analyzed using Kaplan Meier survival analysis and the prognostic factors such as primary tumor status,initial treatment,location of recurrence and treatment strategy after local recurrence were analyzed using Cox regression model.Results The median follow-up was 111 months.The median survival for the 66 patients with recurrence was 99 months,ranging from 3 to 188 months and 5-year survival rate was 60％.Kaplan-Meier analysis revealed statistically significant better survival for patients with unifocal primary tumor,undergoing initial breast conservation surgery,with local recurrence only and undergoing radical local treatment after local recurrence (P =0.003,P =0.017,P =0.050,and P =0.000 respectively).COX regression analysis showed that age at initial diagnosis and radical local treatment after recurrence had influences on post-recurrence survival of patients without distant metastasis (P =O.004 and 0.000 respectively).Conclusion The clinical and pathological features of primary tumor,initial surgery,site of recurrence and treatment strategy after recurrence have influences on prognosis of breast cancer patients with local-regional recurrence.
