Evaluation of endometrial cancer risk in patients with preoperative diagnosis of endometrial atypical hyperplasia
10.3760/cma.j.issn.1674-6090.2013.06.014
- VernacularTitle:术前评估子宫内膜非典型增生患者并存隐匿性子宫内膜癌风险的研究
- Author:
Hongjie YANG
;
Yilin WU
- Publication Type:Journal Article
- Keywords:
Endometrial atypical hyperplasia;
Endometrial carcinoma;
Diagnosis
- From:
Journal of Endocrine Surgery
2013;7(6):494-497
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the frequency of coexisting endometrial carcinoma with preoperative diagnosis of endometrial atypical hyperplasia (EAH).Methods From Apr 2002 to Apr 2007,61 consecutive patients diagnosed as EAH who underwent total hysterectomy in our department were retrospectively analyzed.Patients were stratified as 44 premenopausal cases and 17 menopausal cases.The patients were divided into 2 groups depending on whether or not cancer cells were found by histology in removed uterus (cancer group vs EAH group) to explore valuable predictive risk factors for concomitant endometrial carcinoma through reviewing the clinical data.Logistic regression analysis and logistic regression equation are used to evaluate the risk of coexisting endometrial carcinoma with preoperative diagnosis of endometrial atypical hyperplasia.Results Endometrial thickness and the type of EAH were selected into the equation in premenopausal cases,showing statistically significant differences(P ＜ 0.001) and the overall accuracy was 86.4％.Menopausal years and the type of EAH were selected into the equation in menopausal women,also showing statistically significant differences (P ＜ 0.04)and the overall accuracy was 82.4％.Conclusions Endometrial thickness and the type of EAH are valuable in predicting the risk of endometrial carcinoma in premenopausal women.Menopausal years and the type of EIN are valuable in prediciting the risk of coexistance with endometrial carcinoma in menopausal women.
