Relation between expression of IGF-ⅡR in HER2 positive breast cancer and its significance for prognosis
10.3760/cma.j.issn.1674-6090.2013.05.008
- VernacularTitle:HER2阳性乳腺癌组织胰岛素样生长因子-Ⅱ受体的表达与预后的关系
- Author:
Xiang LU
;
Caiping CHEN
;
Wanxin WU
;
Yanping ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Insulin-like growth factor-Ⅱ receptor (IGF-Ⅱ R);
Human epidermalgrowth factor receptor 2(HER2);
Immunohistochemistry;
Prognosis
- From:
Journal of Endocrine Surgery
2013;7(5):379-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of insulin-like growth factor-Ⅱ receptor(IGF-Ⅱ R) and its relationship with the prognosis of human epidermalgrowth factor receptor 2 (HER2) positive breast cancer.Methods The expression of IGF-Ⅱ R in 104 specimens of HER2 positive breast cancer was evaluated by immunohistochemistry.The expression was rated on 2 scales:negative and positive.The age,pathological type,tumor size,lymph node involvement,status of estrogen receptor(ER),and progesterone receptor(PR) of all the cases were reviewed.The relationship between the expression of IGF-Ⅱ R and the above pathological parameters were analyzed by statistical methods.The relationship between the expression of IGF-Ⅱ R and the disease-free survival and overall survival was studied.Results The positive expression rate of IGF-Ⅱ R was 43.3％ (45/104).The positive rate of IGF-Ⅱ R was significantly higher in the lymph node positive group than in the lymph node negative group (61.5 ％ vs 25.0％,P =0.000).No significant correlation was observed between the expression of IGF-Ⅱ R and age,pathological type,tumor size,status of ER,or PR.The disease-free survival and overall survival was significantly lower in IGF-Ⅱ R positive group than in IGF-Ⅱ R negative group.(The 5-year disease-free survival:62.6％ vs 84.7％,P =0.022; The 5-year overall survival:71.5％ vs 89.6％,P =0.024).Cox regressive analysis showed that the lymph node status was an independent risk factor of disease-free survival and overall survival,while the IGF-Ⅱ R was not.Conclusion The positive expression of IGF-Ⅱ R in HER2 positive breast cancer indicates poor prognosis.The expression of IGF-Ⅱ R may be regulated by insulin-like growth factor-Ⅱ (IGF-Ⅱ).
