Expression of HMGB1, MMP-9 and VEGF-C in papillary thyroid carcinoma
10.3760/cma.j.issn.1674-6090.2013.04.001
- VernacularTitle:高迁移率族蛋白B1、基质金属蛋白酶-9和血管内皮生长因子-C在甲状腺乳头状癌中的表达及意义
- Author:
Pei HUANG
;
Daoming LI
;
Qiwei HUANG
;
Yimin SONG
;
Xia PANG
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
High mobility group box 1;
Matrix metalloproteinase-9;
Vascular endothelial growth factor-C;
Immunohistochemistry;
In situ hybridization
- From:
Journal of Endocrine Surgery
2013;7(4):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of high mobility group box 1 (HMGB1),matrix metalloproteinase-9(MMP-9) and vascular endothelial growth factor-C (VEGF-C)gene in papillary thyroid carcinoma (PTC) and their significance.Methods Expression of HMGB1,MMP-9,VEGF-C proteins and HMGB1 mRNA was detected by technology of immunohistochemistry(SP) and in situ hybridization in 58 cases of PTC tissues,20 cases of thyroid adenoma tissues,25 cases of nodular goiter tissues and 10 cases of normal thyroid tissues.Results Expression of HMGB1,MMP-9,VEGF-C proteins and HMGB1 mRNA in PTC tissues was much higher than that in the 3 non-cancerous tissues (P ＜ 0.05).The positive expression rate of HMGB1,MMP-9 proteins and HMGB1 mRNA was closely associated with the thyroid carcinoma size and lymph node metastasis (P ＜0.05).There was also closely association between the positive expression rate of VEGF-C protein and lymph node metastasis(P ＜ 0.05).The positive expression rate of HMGB1,MMP-9,VEGF-C proteins and HMGB1 mRNA had no association with patients' sex or age(P ＞ 0.05).The expression of HMGB1,MMP-9 and VEGF-C proteins had positive correlation with each other(P ＜ 0.05).The expression of HMGB1 protein and HMGB1 mRNA was also positively correlated with each other(P ＜0.05).Conclusion Expression of HMGB1,MMP-9,VEGFC proteins and HMGB1 mRNA in PTC is correlated with the progress,invasion,metastasis of PTC,by detecting them may help to predict the clinical progress and prognosis.
