Clinical significance of BP1 gene expression in human thyroid cancer
10.3760/cma.j.issn.1674-6090.2013.03.012
- VernacularTitle:BP1基因在甲状腺癌组织中的表达及其临床意义
- Author:
Qilong WANG
;
Xuejun SUN
;
Lingu WANG
;
Shiyun ZHANG
;
Liang CHENG
- Publication Type:Journal Article
- Keywords:
Thyroid cancer;
BP1 gene;
In situ hybridization;
Immunohistochemistry
- From:Journal of Endocrine Surgery
2013;7(3):218-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of BP1 gene in thyroid cancer and its relationship with clinicopathological features of thyroid cancer.Methods BP1 gene expression in 60 cases of thyroid cancer tissues and 20 cases of normal thyroid tissues were detected by in situ hybridization and immunohistochemistry.Results The positive expression rate of BP1 mRNA was 78.3 ％ (47/60) in the 60 cases of thyroid cancer tissues while it was 20％ (4/20) in the 20 cases of normal thyroid tissues detected by in situ hybridization.The difference had statistical significance (P ＜ 0.05).Of the 3 pathological types of thyroid cancer,the positive expression rate of papillary carcinoma was 81.6％ (40/49),follicular carcinoma 85.7％ (6/7),and medullary carcinoma 25.0％ (1/4).The expression of BP1 mRNA had statistical difference between medullary carcinoma and other pathological types like papillary carcinoma and follicular carcinoma (P ＜ 0.05).The positive expression rate of BP1 protein was 93.3％ (56/60)in the 60 cases of thyroid cancer tissues while it was 10.0％ (2/20) in the 20 cases of normal thyroid tissues detected by immunohistochemistry.The difference had statistical significance(P ＜0.05).Conclusion BP1 gene expression is up-regulated in human thyroid cancer and it is related to tumor stage and pathological type but not related to patients' age,sex or lymph node metastasis.
