Relationship between RAD51 135G ＞ C polymorphism and prognosis in triple-negative breast cancer patients
10.3760/cma.j.issn.1674-6090.2014.03.010
- VernacularTitle:三阴乳腺癌患者RAD51 135G＞C多态性与预后的关系
- Author:
Xianfu SUN
;
Suxia LUO
;
Mingge LIU
;
Yaning HE
;
Yingbo SHAO
;
Hui LIU
- Publication Type:Journal Article
- Keywords:
Triple-negative breast cancer;
RAD51 135G ＞ C polymorphism;
Prognosis;
Progress free time;
Overall survival time
- From:
Journal of Endocrine Surgery
2014;8(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between RAD51 135G ＞ C polymorphism and prognosis in triple-negative breast cancer patients by retrospective analysis.Methods The clinical data of 62 triplenegative breast cancer patients were collected.The 62 cases underwent standard chemotherapy and radiotherapy after tumor resection from Jan.2004 to Dec.2010 in Affiliated Cancer Hospital of Zhengzhou University.RAD51 135G ＞ C polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP) technology.The survival curve about progress free and overall survival time were then made.Results The median progress free and overall survival time in triple-negative breast cancer patients with or with-out RAD51 135G ＞ C polymorphism were(77.00 ±5.55)and(89.00 ± 10.40) months vs(99.00 ±4.26)and (103.00 ±4.30) months.The difference had statistical significance(P =0.039 and 0.015 respectively).Conclusion RAD51 135G ＞ C polymorphism is related with prognosis of triple-negative breast cancer patients,which might be a prognostic factor for breast cancer.
