Relationship between expression of MutS homolog2 and CyclinD1 proteins in breast cancer tissues and its significance

VernacularTitle:乳腺癌组织中错配修复基因MSH2和细胞周期蛋白D1表达的相关性及其意义
Author: Jianhua CHEN ; Jie QI ; Ewen XU
Publication Type:Journal Article
Keywords: Breast cancer; MSH2; CyclinD1
From: Journal of Endocrine Surgery 2013;7(3):195-198
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between the expression of MutS homolog2 (MSH2) and CyclinD1 proteins in breast cancer and their clinical significance.Methods Expression of MSH2 and CyclinD1 proteins was detected in 67 cases of invasive ductal carcinoma of the breast by immunohistochemistry.Results The positive expression rate of MSH2 and CyclinD1 proteins was 53.7％ (36/67)and 47.8％ (32/67)respectively.The expression of MSH2 and CyclinD1 protein was closely related to lymph nodes metastasis(P ＜ 0.05).Expression of MSH2 and CyclinD1 protein was negatively correlated with each other in breast cancer(r =-0.251,P =0.040).Conclusion CyclinD1 may play a role in DNA mismatch repair(MMR) system by downregulating the expression of MSH2 and thus influences the tumorigenesis and progression of breast cancer.