Expression and significance of PTTG and Ki67 in fibroadenomatosis and fibroadenomas

VernacularTitle:乳腺多发及单发性纤维腺瘤中PTTG、Ki67的表达及意义
Author: Rongrong ZHANG ; Hongyu HUANG
Publication Type:Journal Article
Keywords: Breast; Fibroadenomatosis; Fibroadenomas; PTTG; Ki67; Immunohistochemical
From:Journal of Endocrine Surgery 2013;7(2):101-103
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between pituitary tumor transforming gene(PTIG) and Ki67 expression and their significance in multiple adolescent breast fibroadenomas (fibroadenomatosis)and single persons(fibroadenomas) and their clinical value.Methods A total of 53 fibroadenomatosis and 160 fibroadenomas specimens in our hospital were collected.All the samples were fixed with 10％ formalin and then embedded with paraffin.The protein expression of PTTG and Ki67 was detected by immunohistochemical staining.The relation between expression of PTTG and Ki67 in fibroadenomatosis was analyzed.Results The positive rate of PTTG and Ki67 was higher in fibroadenomatosis than in fibroadenomas (P ＜ 0.005).Conclusions High expression of PTTG and Ki67 in fibroadenomatosis leads to the proliferation of tumor cell and upregulates tumor angiogenesis.High expression of PTTG and Ki67 may play important roles in tumorigenesis and pathological process of fibroadenomatosis.