Different protein spectrum of breast cancer tissues in predicting curative effects of neoadjuvant chemotherapy
10.3760/cma.j.issn.1674-6090.2013.01.017
- VernacularTitle:乳腺癌组织蛋白质谱的差异对新辅助化疗疗效中的预测
- Author:
Qing LI
;
Kun ZHANG
;
Rongzhan FU
;
He GU
;
Lili ZHANG
;
Kai YUAN
;
Yulong WANG
;
Shouhua CHEN
- Publication Type:Journal Article
- Keywords:
Breast tumor;
Neoadjuvant chemotherapy;
Proteomics
- From:Journal of Endocrine Surgery
2013;7(1):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out related proteins that could possibly predict curative effects of neoadjuvant chemotherapy(NACT) by applying surface-enhanced laser desorption/ionization time-of-flight mass spectrometry(SELDI-TOF MS)to detect the difference in protein spectrum of breast cancer tissues.Methods Cancer tissue samples from 30 cases of breast cancer patients were detected by SELDI-TOF MS before NACT to get protein spectrum of breast cancer tissues.After NACT,the curative effects were evaluated according to RECIST standard and patients were divided into effective group(19 cases with complete response or partial response)and invalid group (11 cases with stable disease or progressive disease).Results 11 different protein peaks (P ＜ 0.05) were screened out:3491 Da(t =3.189 P =0.004),5158 Da(t =3.897 P =0.001),5360 Da(t =2.157 P =0.04),7549 Da(t =2.173 P=0.038),8451 Da(t =2.258 P =0.032),8694 Da(t =3.234 P =0.003),9089 Da (t =2.653 P =0.013),10528 Da(t =3.127 P =0.004),13445 Da(t =2.231 P =0.034),15118 Da(t =3.255 P =0.003),and 44065 Da(t =2.554 P =0.017).They were all expressed higher in effective group than in invalid group.The difference had statistical significance(P ＜ 0.05).Conclusion SELDI-TOF MS technology can screen out protein spectrum sensitive to NACT,providing evidences for breast cancer patients whether or not taking NACT.
