Expression and clinical significance of BFGF and BFGFR in papillary thyroid carcinoma
10.3760/cma.j.issn.1674-6090.2013.01.016
- VernacularTitle:碱性成纤维细胞生长因子及其受体在甲状腺乳头状癌的表达和意义
- Author:
Chun YE
;
Zhen LIU
;
Dongxu CUI
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
BFGF;
BFGFR;
Invasion;
Metastasis;
Immunohistochemistry
- From:Journal of Endocrine Surgery
2013;7(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of BFGF factor(BFGF) and basic fibroblast growth factor receptor(BFGFR) in papillary thyroid carcinoma (PTC).Methods 80 casesof PTC and 10 cases of nodular goiter underwent surgical treatment from Mar.2001 to May.2005 in Shengjing Hospital of China Medical University.Samples were collected and immunohistochemistry staining was performed to detect the expression of BFGF and BFGFR.Results The expression rate of BFGF and BFGFR was 72.5％ (58/80)vs 70.0％ (56/80) in PTC,and 0.0％ (0/10) vs 0.0％ (0/10) in nodular goiter.The difference had statistical significance(P ＜0.05).The expression level of BFGF and BFGFR in PTC had no relation with sex,age or tumor size(P ＞0.05),but has relation with lymph node metastasis and UICC stage(P ＜0.05).The expression of BFGF was positively correlated with the expression of BFGFR (r =0.330,P =0.003).Conclusions BFGF and BFGFR are highly expressed in PTC but have no expression in nodular goiter or normal thyroid tissues.The expression of BFGF and BFGFR in PTC is closely related to lymph node metastasis and UICC stage,indicating the 2 may be involved in tumorigenesis,invasion,and metastasis.
