The expression of mismatch repair gene in pancreatic carcinoma
10.3760/cma.j.issn.1674-6090.2012.06.008
- VernacularTitle:胰腺癌错配修复基因的表达
- Author:
Guohui LIU
;
Yonghua YAO
;
Di YAO
;
Xiaohong DU
- Publication Type:Journal Article
- Keywords:
Pancreatic carcinoma;
Mismatch repair gene;
Gene expression
- From:
Journal of Endocrine Surgery
2012;6(6):391-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of mismatch repair gene hMLH1 in pancreatic carcinoma and its clinicopathological significance.Methods hMLH1 was extracted from 60 cases of pancreatic carcinoma tissues and 60 cases of normol pancreatic tissues.hMLH1 expression in pancreatic carcinoma and normal tissues was detected by SP immunohistochemical staining.Results The strong,weak and loss expression of hMLH1 in pancreatic carcinoma tissues and normal pancreatic tissues was 0 vs 83.33% (50/60),31.7% (19/60)vs 16.67% (10/60),and 68.3% (41/60) vs 0 respectively.The protein expression of hMLH1 was not related to patient's age,tumor location,or pathological types (P > 0.05),but it was related to lymph node metastasis (x2 =8.579,P =0.004),clinical stage (x2 =9.586,P =0.002) and pathological differentiation (x2 =20.372,P =0.001).Conclusion The loss expression of hMLH1 has a correlation with pancreatic carcinogenesis,differentiation degree,and disease progression.