Galectin-3 in differential diagnosis between benign and malignant thyroid follicular tumor
10.3760/cma.j.issn.1674-6090.2013.05.024
- VernacularTitle:Galectin-3免疫组化检测对甲状腺滤泡性肿瘤良恶性鉴别的意义
- Author:
Donghang HUANG
;
Zhenhui YOU
;
Huashui LI
;
Ailong ZHANG
;
Hang WANG
;
Lizhen QIU
;
Qiang LIN
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Immunohistochemistry;
Gene expression
- From:Journal of Endocrine Surgery
2013;7(5):424-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of Galectin-3 in thyroid follicular tumors and its clinical significance in differential diagnosis between benign and malignant thyroid follicular tumor.Methods The expression of Galectin-3 in 120 cases of thyroid follicular carcinoma and 80 cases of thyroid follicular adenoma was detected by immunohistochemical technique.Results The expression rate of Galectin-3 in thyroid follicular carcinoma was significantly higher than that in follicular adenoma(84％ vs 19％,P ＜ 0.01).Strong positive expression of Galectin-3 was found in 40％ cases of thyroid follicular carcinoma and no case of thyroid follicular adenoma.Conclusions The expression of Galectin-3 can be regarded as an important parameter for differential diagnosis between benign and malignant thyroid follicular tumor.
