Trends in the Eradication Rates of Helicobacter pylori Infection in Daegu and Gyeongsangbuk-do, Korea: Multicenter Study over 13 Years.
- Author:
Yeoun Su JUNG
1
;
Si Hyung LEE
;
Chan Seo PARK
;
Myung Jin OH
;
Kyeong Ok KIM
;
Byung Ik JANG
;
Seong Woo JEON
;
Min Kyu JUNG
;
Kyung Sik PARK
;
Eun Soo KIM
;
Kwang Bum CHO
;
Jin Tae JUNG
;
Joong Goo KWON
;
Eun Young KIM
;
Wan Jung KIM
;
Chang Heon YANG
Author Information
- Publication Type:Original Article ; English Abstract ; Multicenter Study
- Keywords: Helicobacter pylori; Eradication
- MeSH: Adult; Aged; Amoxicillin/therapeutic use; Anti-Bacterial Agents/*therapeutic use; Clarithromycin/therapeutic use; Disease Eradication/*trends; Drug Administration Schedule; Drug Therapy, Combination; Endoscopy, Gastrointestinal; Esomeprazole/therapeutic use; Female; Helicobacter Infections/*drug therapy/pathology; *Helicobacter pylori; Humans; Logistic Models; Male; Middle Aged; Omeprazole/therapeutic use; Proton Pump Inhibitors/*therapeutic use; Rabeprazole/therapeutic use; Republic of Korea; Retrospective Studies; Treatment Outcome
- From:The Korean Journal of Gastroenterology 2014;63(2):82-89
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND/AIMS: The eradication rates of Helicobacter pylori infection have been reported to have decreased over the years due to antibiotics resistance. The aim of this study is to investigate the trend of eradication rates of first-line triple therapy for H. pylori over the past 13 year period, and to evaluate factors affecting H. pylori eradication in Daegu and Gyeongsangbuk-do, Korea. METHODS: A total of 2,982 patients with H. pylori infection who were treated with either 1 week or 2 weeks first-line therapy (proton pump inhibitor [PPI], amoxicillin, and clarithromycin) from January 1999 through December 2011 were included in this study. Data were collected by retrospectively reviewing the medical records. RESULTS: The overall H. pylori eradication rate was 87.2%. The eradication rates from 1999 to 2011 fluctuated between 78.0% and 95.7%, but no definite evidence of a decreasing tendency was seen over the 13 year period (p=0.113). Furthermore, there was no significant difference in the eradication rate according to the duration of therapy (p=0.592). However, there was a significant difference in the eradication rate among various PPIs (p<0.01). CONCLUSIONS: There was no decreasing trend in the H. pylori eradication rate over the past 13 years in Daegu and Gyeongsangbuk-do, Korea. There also was no difference in the eradication rates depending on duration of therapy. However, a significant difference was noted among various PPIs.
