Diagnostic value of dynamic contrast enhanced MRI in the angiogenesis and invasion of ovarian tumors
10.3760/cma.j.issn.1674-6090.2015.02.019
- VernacularTitle:磁共振动态增强成像对卵巢肿瘤血管生成及侵袭的诊断价值
- Author:
Weiping ZHOU
;
Ping LIN
;
Sujian LIN
- Publication Type:Journal Article
- Keywords:
Dynamic contrast enhanced magnetic resonance imaging;
Ovarian tumors;
Angiogene-sis;
Invasion;
VEGF;
MMP-2
- From:
Journal of Endocrine Surgery
2015;(2):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of dynamic contrast enhanced MRI (DCE-MRI)in angiogenesis and invasion of ovarian tumors .Methods 98 patients with pathological-confirmed ovarian tumors without any treatment underwent plain MRI and DCE-MRI before operation .The plain MR images and DCE-MRI data were retrospectively analyzed .Value of Ktrans and Ve was detected by pharmacokinetic model .The expression of VEGF and MMP-2 in ovarian tumors was examined by immunohistochemistry .The correlation between DCE-MRI parameters and immunohistochemical results was analyzed .Results The expression of VEGF and MMP-2 was sig-nificantly higher in the malignant group compared with that in the benign group (both P<0.05).The value of Ktrans and Ve was significantly lower in the benign group compared with that in the malignant group ( both P<0.05) .The value of Ktrans and Ve was positively correlated with the expression of VEGF and MMP-2.Conclusion DCE-MRI can noninvasively evaluate the angiogenesis and invasion of ovarian tumors in vivo , which has important signifi-cance for clinical treatment and prognostic assessment .
