Follow-up of the serum concentration of pituitary hormones after spontaneous subarachnoid hemorrhage
10.3760/cma.j.issn.1674-6090.2014.06.015
- VernacularTitle:自发性蛛网膜下腔出血患者垂体前叶功能变化研究
- Author:
Rongcai LIU
;
Qiang HUANG
;
Weiming DAI
;
Yuanqing JIE
;
Guofeng YU
;
Xiaofeng FAN
;
An WU
- Publication Type:Journal Article
- Keywords:
Spontaneous subarachnoid hemorrhage;
Pituitary hormone;
Cerebral vasospasm
- From:
Journal of Endocrine Surgery
2014;(6):491-494
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk of pituitary dysfunction for spontaneous subarachnoid hemor -rhage( s-SAH) patients and to evaluate its correlation with clinical data .Methods 63 cases of patients with s-SAH were selected.Indicators(serum adrenocorti cotrophic hormone (ACTH), growth hormone(GH), insulin-like growth factor-1(IGF-1), thyroid stimulating hormone(TSH), thyroxine(T4), triiodothyronine(T3), folli-cle-stimulating hormone(FSH), luteinizing hormone(LH), total testosterone(in males), estradiol(in females) and prolactin)dynamic observation were tested 7 days, 1 year, 2 years, 3 years after the onset.Results Thirty patients( 47.6%) had some type of pituitary dysfunction .ACTH deficiency was the most frequent disorder (14.3%), followed by GH deficiency(12.7%), hypogonadatrophic(6.3%), hypothyroidism(3.2%)and high prolactin(1.6%).six patients(9.5%)showed deficiencies in more than one axis .Hormone deficiency was relat-ed to vasospasm, Fisher grade 4(P<0.05)and recovery time.Conclusions A greater incidence of hormone de-ficiency after s-SAH was related with vasospasm , Fisher grade and recovery time .Follow-up time should be ex-tended.
