Perioperative use of hydrocortisone in retroperitoneal laparoscopic surgery for Cushing's syndrome
10.3760/cma.j.issn.1674-6090.2014.06.018
- VernacularTitle:氢化可的松在后腹腔镜手术治疗皮质醇增多症围手术期的应用研究
- Author:
Kunlong TANG
;
Lupeng LI
;
Liang WANG
;
Liming LI
- Publication Type:Journal Article
- Keywords:
Cushing syndrome;
Hydrocortisone;
Hormone replacement therapy
- From:
Journal of Endocrine Surgery
2014;(6):503-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application and effect of hydrocortisone during perioperation of retroperitoneum laparoscopic surgery for Cushing's syndrome.Methods Data of 56 cases of Cushings's syndrome treated by hormone replacement therapy of hydrocortisone were retrospectively analyzed .The hormone replacement therapy was as the following:no hormone before surgery, intravenous drip of hydrocortisone during and the 1st and 2nd day after surgery, oral intake of hydrocortisone from the 2nd after surgery.Clinical symptoms were observed and plasma,24h urine cortisol levels were intermittently measured after the surgery to evaluate the effects of treatment . Results 2 cases had slight cortical dysfunction symptoms, then back to normal after receiving larger dose of hydro-cortisone.6 cases had blood cortisol levels below the normal range , but they did not have cortical dysfunction symp-toms, and at the same time their 24h urine cortisol levels were normal .Urine cortisol concentration significantly de-creased on the 7th day after surgery, and had significant difference compared with that before surgery .Plasma cortisol concentration significantly decreased on the 6th, 7th day after surgery, and had significant difference compared with that before operation.All the cases recovered well.Conclusion Perioperative hydrocortisone replacement in retroper-itoneum laparoscopic surgery for Cushing's syndrome is safe.
