The significance of expression of VEGFR-3 signaling associated protein in thyroid cancer
10.3760/cma.j.issn.1674-6090.2010.04.003
- VernacularTitle:甲状腺癌VEGFR-3信号途径相关蛋白表达的意义
- Author:
Guohu GUO
;
Huiyu HUANG
;
Guangrong LIN
;
Gaoyang CAI
;
Ziqun LIAO
- Publication Type:Journal Article
- Keywords:
Thyroid cancer;
Vascular endothelial growth factor receptor-3;
Metastasis
- From:
Journal of Endocrine Surgery
2010;04(4):222-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the involvement of VEGFR-3 signaling pathway in lymphatic metastasis of thyroid cancer. Methods The expression of VEGFR-3 mRNA in thyroid carcinoma and normal thyroid tissue was detected by RT-PCR. The expression of VEGFR-3 mRNA and the lymphatic vessel density (LVD) in thyroid carcinoma and normal thyroid tissue was measured by immunohistochemical staining. Results All thyroid cancer samples expressed VEGFR-3 and the expression rate of VEGFR-3 in thyroid carcinoma was significantly higher than that in the normal thyroid group ( P ＜ 0. 05 ). LVD in thyroid cancer was significantly higher than that in normal control. LVD with lymph nodes metastasis ( N + ) was significantly higher than that without lymph node metastasis (NO) (P ＜ 0. 05). Conclusions There is upregulatin of VEGFR-3 expression in thyroid carcinoma. The higher the expression of VEGFR-3, the severer of lymph node metastasis. VEGFR-3 receptor-mediated signal transduction pathway might be an important factor of thyroid cancer lymph node metastasis.
