Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
- VernacularTitle:Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
- Author:
Hongying YANG
;
Wenmeng ZHANG
;
Wenwen YANG
;
Ting ZHAO
;
Lixin SUN
- Publication Type:Journal Article
- Keywords:
16-dehydropregnenolone;
intramuscular administration;
pharmacokinetics;
high performance liquid chroma- tography
- From:
Journal of Pharmaceutical Analysis
2011;01(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacokinetics of 16-dehydropregnenolone （16-DHP）, a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a single intramuscular administration （40 mg/kg）. The concentration of 16-DHP in rat plasma was determined by a high performance liquid chromatography （HPLC） method with UV detection. Levonorgestrel was used as the internal standard （IS）. The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a single intramuscular administration, the maximum plasma concentration （Cmax） was （289±25）ng/mL, time to reach Cmax（tmax） was （0.38±0.14） h, the elimination half-life （t1/z） was （2.5±1.1）h, the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration （AUC（0-t）） was （544± 73）ng· h/mL. The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection.
