Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
- VernacularTitle:Flow injection chemiluminescence determination of loxoprofen and naproxen with the acidic permanganate-sulfite system
- Author:
Lijuan WANG
;
Yuhai TANG
;
Yanghao LIU
- Publication Type:Journal Article
- Keywords:
chemiluminescence;
KMnO4;
loxoprofen;
naproxen
- From:
Journal of Pharmaceutical Analysis
2011;01(1):51-56
- CountryChina
- Language:Chinese
-
Abstract:
A novel flow injection chemiluminescence(CL)method for the determination of loxoprofen and naproxen was proposed based on the CL system of KMnO4 and Na2SO3 in acid media.The CL intensity of KMnO4-Na2SO3 was greatly enhanced in the presence of loxoprofen and naproxen.The mechanism of the CL reaction was studied by the kinetic process and UV-vis absorption and the conditions were optimized.Under optimized conditions,the CL intensity was linear with loxoprofen and naproxen concentration in the range of 7.0×10^-8-1.0×10^-5g/mL and 2.0×10^-7-4.0×10^-6g/mL with the detection limit of 2.0×10-8g/mL and 3.0×10-8g/mL(S/N=3),respectively.The relative standard deviations were 2.39% and 1.37% for 5.0×10^-7g/mL naproxen and 5.0×10^-7g/mL loxoprofen(n=10),respectively.The proposed method was satisfactorily applied to the determination of loxoprofen and naproxen in pharmaceutical preparations.