THE PROSPECTIVE STUDY OF RELATIONSHIP BETWEEN LOW SELENIUM AND KASHIN-BECK DISEASE
- Author:
Xiong GUO
;
Dexiu DING
;
Lingxia ZENG
;
Zhidao YU
;
Fengshi CHEN
;
Huayin BI
;
Zengqin ZHAO
;
Jiuxing WANG
- Publication Type:Journal Article
- Keywords:
Kashin-Beck disease;
selenium;
new case;
prospective study
- From:
Journal of Pharmaceutical Analysis
1999;11(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
The relationship of cause-result between low selenium (Se) and Kashin-Beck disease (KBD) was probed by the prospective study of epidemiological method with regarding low-Se as an exposure factor in this paper. 597 healthy children lived in KBD areas with low, middle and high prevalence were divided into the low-Se exposed group and the non-low-Se exposed group according to their Se content in hair. The low-Se exposed group was divided into three subgroups, such as Se content in hair≤110 ng/g, 110 ng/g＜Se content in hair≤150 ng/g and 150 ng/g＜Se content in hair≤200 ng/g, respectively. Six new cases of the total with KBD (incidence was 0.574% person-year) were found in the low-Se exposed group during three years period of the investigation. No new case was found in the non low-Se exposed group . KBD incidence was not significantly different between those two groups. Two new cases were found in children with Se content in hair kept below 110 ng/g during three years (incidence: 1.21% person-year). SMR in each group indicated that the new cases observed in the low-Se exposed group was remarkable lower than the new cases expected. It was not observed that the dose-response relationship between low-Se and KBD, and was not supported that the low-Se was a predominant factor to cause KBD.
