ANTIPROLIFERATIVE ACTIVITY OF HUMAN IFN-γ-EGF3 FUSION PROTEIN ARE RELATED TO ITS EGF RECEPTOR COMPETITION
- Author:
Xiaobing ZHANG
;
Yonglie CHU
;
Wangqiu CHEN
;
Yunde HOU
- Publication Type:Journal Article
- Keywords:
IFN-γ fusion protein;
antitumor activity;
epidemal growth factor (EGF) receptor
- From:
Journal of Pharmaceutical Analysis
1999;11(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between antiproliferative effect of human IFN-γ-EGF3 fusion protein and the influence of EGF receptor binding activity has been studied on A431 cell line. Antiproliferative activity of human IFN-γ-EGF3 was higher than that of its parent IFN-γ. In the 125 I-EGF receptor competition experiment, the inhibition of EGF receptor binding capacity on the target cells was observed in the treatments of human IFN-γ or IFN-γ-EGF3, but the later was more significant. Our data suggests that the antiproliferative effects by IFN-γ and its fusion protein are closely related to their EGF receptor competitions.
