ANTIVIRAL TESTS OF METHYLENE BLUE INJECTION ON VZV IN VITRO
- Author:
Xiaohui GU
;
Wenqi WU
;
Wenning SHI
;
Yonglie CHU
- Publication Type:Journal Article
- Keywords:
methylene blue injection;
cell culture;
VZV;
cytopathic effect
- From:
Journal of Pharmaceutical Analysis
1999;11(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Methylene blue injection has a stronger direct inactivation on VZV in vitro. When the injection was diluted from 1:16 to 1:128, which was obvious (P＜0.01 and P＜0.05). The MIC was 1:222, the IC50 was 1:135 and IC90 was 1:77. The results of microcellculture method showed when the injection was diluted from 1:16 to 1:64, it also effectively inhibited the proliferation of VZV in WISH continuous cell-lines (P＜0.01 and P＜0.05). The MIC was 1:95, the IC50 was 1:45 and the IC90 was 1:21.
