CORRELATION OF THE MAGNETIC MOTOR EVOKED POTENTIAL TECHNIQUE WITH PATHOLOGICAL CHANGES ASSOCIATED WITH SPINAL CORD INJURY IN ADULT CATS
- Author:
Youfen LI
;
Zhe YANG
;
Min SU
;
Junchang CHEN
;
Longzhu ZHAO
;
Guolian YUAN
;
Zongying LI
;
Dazhi YANG
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
pathologic change;
motor evoked potentials
- From:
Journal of Pharmaceutical Analysis
1999;11(1):65-69
- CountryChina
- Language:Chinese
-
Abstract:
To determine whether the pathological changes caused by injury to the spinal cord can be correlated with values obtained by the Magnetic Motor Evoked Potential (MEPs) technique, we studied spinal cords from 41 adult cats who were divided into 4 groups. The groups ranged from normal cats whose spinal cords were not compressed, to slightly, moderately and severely injured. MEPs were recorded before compression and in 30 minutes, 6 hours, 1 week, 2 week and 4 week after the compression unit was installed. Pathological changes with increased pressure were seen in blood vessels, nerve cells and fibers, Nissl substance and the central canal. A reversal of pathological changes was observed in slight or moderate injury during the 4 weeks of the experiment. Extensive injury, however, caused irreversible changes in the nerve cells with loss of motor function. The latency of MEPs at 30 minutes and 6 hours in the slightly injured group was 0.37 and 0.38 times greater than the baseline and returned to normal levels in 4 weeks. In the moderately injured group, the latency was increased 0.77 and 0.81 times and in the severely injured 1.32 and 1.36 times over the baseline. Recovery in the second group was partial and not at all in the severely injured. Thus, there appears to be good correlation between observed pathological changes, motor functions and MEPs.
