APOPTOSIS AFTER SPINAL CORD INJURY IN RATS
- Author:
Zanli JIANG
;
Junchang CHEN
;
Kunzheng WANG
;
Bing BAI
- Publication Type:Journal Article
- Keywords:
apoptosis;
spinal cord injury;
rat
- From:
Journal of Pharmaceutical Analysis
2000;12(1):55-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To confirm the role played by apoptosis in spinal cord injury. Methods 36 rats models of spinal cord injury were made by Allen method. Histological examinations using HE staining and in situ end-labeling were used to observe apoptosis in spinal cord tissues from 1h to 21d after injury. Results HE staining sections showed hemorrhage and necrosis, neuronal degeneration and gliai cell proliferation. In situ end-labeling sections showed the appearance of apoptosis in both gray and white matter as well as in both central and surrounding region. The number of apoptotic cells increased from 12h after injury, increased to the peak at 4d and declined to normal at 21d. Conclu sion The results suggest that apoptosis, especially glial apoptosis, plays a role in the pathogenesis of spinal cord in jury.
