THE EFFECT OF Ge-132 ON ULTRASTRUCTURE OF CULTURED MELANOCYTES
- Author:
Kuanhou MU
;
Jie FENG
;
Hanqing XU
- Publication Type:Journal Article
- Keywords:
Ge-132;
melanocytes;
ultrastructure
- From:
Journal of Pharmaceutical Analysis
2000;12(2):148-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the effect of Ge-132 on the growth of melanocytes. Mothods Melanocyes from epidermis were cultured and purified ;the second generation of the cell was used for study ;the cells were divided into two groups randomly,to group A, Ge-132 was added to the media at 0.04mg/L ;to group B ,common culturing method was used without Ge-132. After 5d, the cells were seperated by digestion for study by transmission electronic micro- scope. ResultsCompared to group B, the vacuioes of the cells were increased,mitochondria distended, endoplasmic reticulum dilated and the number of melanosome declined in the group A. Conclusion Ge-132 can inhibit the melanocyte＇s growth at a certain concentration and might be used for treating pigmented diseases.
