PLATELET ACTIVATION AND ENDOTHELIAL CELL IMPAIRMENT ON ADRENOGLUCOCORTISONE-INDUCED OSTEONECROSIS
- Author:
Yonggang WU
;
Junchang CHEN
;
Kunzheng WANG
- Publication Type:Journal Article
- Keywords:
osteonecrosis;
platelet;
endothelial cell
- From:
Journal of Pharmaceutical Analysis
2000;12(2):151-154
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of the platelet activation and the endothelial cell impairment on the osteonecrosis. Methods The contents of TXB2,6-keto-PGF1a, GMP-140 and TM in different periods of animal models of adrenoglucocortisone-induced osteonerosis were measured by the radio-immunity method. ResultsThe contents in group B increased dramatically from 24h after the injection of adrenoglucocortisone, and the contents of GMP-140 and TM from 3d after injection increased with significant difference from group A. Conclusion The results suggest that the early emergence of the platelet activation and endothelial cell impairment models induced by horse serum and adrenoglucocortisone plays a role in the formation of the osteonecrosis.
