A NEW MODEL AND IMPROVED CABLE FUNCTION FOR REPRESENTING THE ACTIVATING PERIPHERAL NERVES BY A TRANSVERSE ELECTRIC FIELD DURING MAGNETIC STIMULATION
- Author:
Hui YU
;
Chongxun ZHENG
;
Haiyan WANG
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
Transverse field;
peripheral nerves;
cable equation;
trans-membrane potential
- From:
Journal of Pharmaceutical Analysis
2005;17(1):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective Previous studies of peripheral nerves activation during magnetic stimulation have focused almost exclusively on the cause of high external parallel electric field along the nerves, whereas the effect of the transverse component has been ignored. In the present paper, the classical cable function is modified to represent the excitation of peripheral nerves stimulated by a transverse electric field during magnetic stimulation. Methods Responses of the Ranvier nodes to a transverse-field are thoroughly investigated by mathematic simulation. Results The simulation demonstrates that the excitation results from the net inward current driven by an external field. Based on a two-stage process, a novel model is introduced to describe peripheral nerves stimulated by a transverse-field. Based on the new model, the classical cable function is modified. Conclusion Using this modified cable equation, the excitation threshold of peripheral nerves in a transverse field during MS is obtained. The modified cable equation can be used to represent the response of peripheral nerves by an arbitrary electric field.
