Research on pharmacokinetics of high-dose tamoxifen in non-small cell lung cancer patients
- Author:
Ling CHEN
;
Xu LI
;
Rong LI
;
Xinhan ZHAO
;
Rui LI
;
Xiaohui ZHENG
;
Sicen WANG
- Publication Type:Journal Article
- Keywords:
tamoxifen;
pharmacokinetics;
high-performance liquid chromatography;
non-small cell lung cancer;
resistance to drug
- From:
Journal of Pharmaceutical Analysis
2007;19(2):204-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics of tamoxifen at a high dosage, which will offer a theoretical support for an appropriate clinical use of the medicine in non-small cell lung cancer (NSCLC) patients. Methods Three qualified NSCLC patients are selected and given tamoxifen (TAM) 160 mg per Os. Blood samples were collected at different times and then analyzed by high-performance liguid chromatography. The PK-GRAPH program was used to obtain the parameters. Results The concentration-time courses of the TAM 160 mg were fitted to one-compartment model. The pharmacokinetic parameters were estimated as follows: Tmax (6.35±1.24)h, Cmax (217.39±7.71)ng/Ml, AUC (12 127.39±636.16)ng·h/Ml and T1/2ke (34.13±2.97)h. Conclusion TAM 160mg one day per Os cannot reach the effective maintenance concentration in vivo required for reversing MDR in vitro. Loading-maintenance dose strategy is recommended to study the pharmacodynamics of tamoxifen at a high dosage in NSCLC patients.
