Reducing intimal hyperplasia in vein grafts harvested by a no-touch harvesting technique
- Author:
Haichen WANG
;
Wujun XUE
;
Miaomiao LIU
- Publication Type:Journal Article
- Keywords:
vein groft;
no-touch harvesting technique;
intimal hyperplnsia
- From:
Journal of Pharmaceutical Analysis
2009;21(2):138-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of no-tonch harvesting technique in reducing vein graft intimal hyperplasin. A4othods This longitudinal trial compared graft ungiestenosis of two groups undergoing jugular vein to carotid artery interposition grafting in rabbit model. Conventional group: 12 rabbits had their veins stripped, distended, and stored in heparinized saline solution. No-touch group: 12 rabbits had veins removed with surrounding tissues, but were not distended, and stored in heparinized blood. The grafts were removed 4 weeks following grafting, and morphometry and immunohistochemistry assessment were performed. Results The intimal thickness, degree of anginstennsis and proliferation index of vascular smooth muscle cells of no-touch group were significantly reduced (P< 0.01) compared with those of the conventional group. The proliferating cell nuclear antigen pnsitive-staining cells were significantly increased (P<0.01) in the conventional group compared with whose in the no-touch group. Conclusion Harvesting the vein graft with no-touch harvesting technique could significantly reduce intimul hyperpinsin of the vein graft.
