Expression and role of Tie-2 in rectal carcinoma
- Author:
Zhenhua MA
;
Kang WANG
;
Mao ZHANG
;
Weihua SHANG
- Publication Type:Journal Article
- Keywords:
Tie-2;
rectal carcinoma;
immunohistochemistry
- From:
Journal of Pharmaceutical Analysis
2010;22(1):66-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Tie-2 in rectal carcinoma and its relationship with invasion and metastasis in rectal carcinoma. Materials S-P immunohistochemical assay was used to detect the expression of Tie-2 in 40 cases of rectal carcinoma and 10 cases of normal rectal tissues. Results Tie-2 was mainly localized in the cytoplasm and nucleus of vascular endothelial cells in cancerous tissues and partly in the cytoplasm of some cancerous cells. The expression of Tie-2 in rectal carcinoma was significantly higher than that in normal rectal tissues (P<0.05); however, Tie-2 expression was not associated with differentiation, invasion depth and Dukes stage (P>0.05), but with lymphatic metastasis (P<0.05). Conclusion Tie-2 plays a key role in carcinogenesis and lymph node metastasis of rectal carcinoma.
