CT guided microwave ablation combined with gemcitabine and cisplatin regimen for the treatment of advanced squamous cell carcinoma of the lung
10.3969/j.issn.1005-1678.2017.08.102
- VernacularTitle:CT引导下微波消融联合吉西他滨与顺铂方案化疗治疗中晚期肺鳞癌临床观察
- Author:
Zhigang TAO
;
Jian ZHOU
- Keywords:
squamous cell carcinoma of the lung;
advanced stage;
gemcitabine;
cisplatin;
microwave ablation
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(8):243-244,247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of gemcitabine and cisplatin chemotherapy combined with CT guided microwave ablation used in treatment of advanced squamous cell lung cancer. Methods 76 patients with lung squamous carcinoma in our hospital from April 2013 to July 2015 were selected,and randomly divided into treatment group and control group,38 cases in each groups. The control group were treated with gemcitabine and cisplatin chemotherapy. The patients in the treatment group in the control group based on the combined CT guided ablation under microwave, after the end of treatment to evaluate the efficacy of the two groups of patients, observe two groups of patients with adverse reactions, and were followed up for 1-2 years. Results The total effective rate of treatment group was significantly higher than the control group (P<0.05); pneumothorax treatment group after microwave ablation in patients with 2 cases, 3 cases of hemoptysis, 2 cases of fever, recovered after symptomatic treatment. The adverse reactions of the two groups due to chemotherapy caused by comparison of the rate of no significant difference; the treatment group of patients with PFS was significantly longer than the control group, the 1 year survival rate and 2 year survival rate was significantly higher than the control group(P<0.05). Conclusion Gemcitabine combined with cisplatin chemotherapy regimen combined with CT guided microwave ablation is effective in the treatment of advanced squamous cell lung cancer, and is worthy of clinical promotion.
