Effect of P-selectin Deletion on Intestinal Tumorigenesis in 15,24-week-old ApcMin/+ Mice
- VernacularTitle:P-选择素敲除对自发肠道腺瘤ApcMin/+小鼠中晚期肿瘤生长的作用
- Author:
Yajun HE
;
Jinghua CAO
;
Mengshi LI
;
Simei GUO
;
Lijing WANG
;
Cuiling QI
- Keywords:
P-selectin;
intestinal tumor;
genetically engineered mice
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(4):494-497,544
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the effect of P-selectin on the intestinal tumorigenesis in the 15,24-week-old ApcMin/+ mice.[Methods] Male ApcMin/+ mice were mated with female P-selectin knockout (P-sel-/-) mice to generate AMin/+Ps-/-mice.The diameters and numbers of the intestinal tumors in the intestines of ApcMin/+ and AM/+ps-/-mice were measured using an inverted microscope.The tumor volumes were measured using the following equation:volume =0.52 × (length × width2).[Results] There were no significant difference between the volume and number of intestinal tumor in 15-week-old ApcMin/+ mice and 15-week-old A+ P-mice.The volume and number of intestinal tumor were significantly increased in 24-week-old A+P-mice compared to 24-weekold ApcMin/+ mice.P-selectin deletion significantly prolonged the survival time of ApcMin/+ mice.[Conclusions] P-selectin deletion promotes the intestinal tumorigenesis in the 24-week-old ApcMin/+ mice.
