PD-1/PD-L1 Expressed on T Cell and Bladder Cancer Cell
- VernacularTitle:PD-1/PD-L1在膀胱癌患者外周血T细胞和肿瘤细胞表达
- Author:
Tao HUANG
;
Zhaolin LONG
;
Shihao WU
;
Qingsheng HUA
;
Xinji ZHANG
- Keywords:
PD-1/PD-L1;
CD8+ T lymphocyte;
bladder cancer cell;
immunohistochemistry
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(4):628-631,封3
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the characteristics of PD-1/PD-L1 expressed on T cell and bladder cancer cell and clinical significance.[Methods] 64 patients with primary bladder cancer were into experiment group and 10 normal people were into control group.Peripheral bloods were used to test the PD-1 expressed on CD8+ T lymphocytes by flow cytometry.Immunohistochemistry staining was used to detect the PD-L1 expression in tumor and normal specimen.[Results] PD-1 expressed on CD8+T lymphocytes was (2.25 ± 0.60)％ in experiment group and (0.68 ± 0.17)％ in control group,respectively (P ＜ 0.001).And the PD-1 expression on T cell in invasive bladder cancer patient was significant higher than superficial bladder cancer patients [(3.04 ± 0.46)％ vs (0.68± 0.17)％,P ＜ 0.001].The expression of PD-L1 in experiment group was higher than control group,(26/64 vs 0/15,P ＜ 0.001).But there was no different between invasive and superficial bladder cancer patients,(41.3％ vs 38.8％,P ＞ 0.01).[Conclusions] Expression of negative stimulatory molecule PD-1 in CD8+T lymphocytes of peripheral blood is significantly correlated with bladder cancer advanced.Bladder cancer cell was strongly expressed PD-L1,and this expression is not related to cancer advanced.
