Endoscopic submucosal dissection in treatment of gastrointestinal neuroendocrine neoplasms
10.3969/j.issn.1007-1989.2016.12.019
- VernacularTitle:内镜黏膜下剥离术治疗胃肠道神经内分泌肿瘤的临床观察
- Author:
Huijun ZHUANG
;
Xude SHEN
;
Jinzhong CHEN
;
Liqing YAO
;
Hong SU
;
Tianxia LEI
;
Weilin YANG
;
Jianhai WU
;
Yongsheng ZHENG
;
Xiumei LI
;
Liyun PAN
;
Shiqun LI
- Keywords:
endoscopic submucosal dissection (ESD);
neuroendocrine neoplasms (NENs);
gastrointestinal
- From:
China Journal of Endoscopy
2016;22(12):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility and efifcacy of endoscopic submucosal dissection (ESD) for gastrointestinal neuroendocrine neoplasms (GI-NENs).Methods 52 patients with conifrmed histological diagnosis of GI-NENs performed ESD from January 2011 to December 2015 were included. The endoscopic morphology of tumor was summarized. Complete resection rate, complications, clinicopathological characteristics, and follow-up results were evaluated.Results There were 16 cases of stomach, 9 cases of colon and rectum 27 cases. Most of the lesions were submucosal uplift. A few of lesions looked like polyps. All the lesions were one-time whole diseased. 44 lesions were NET-G1, 8 lesions were NET-G2. Complete resection rate was 94.23%. 2 cases of rectal lesions infringemented intrinsic muscle layer, and got additional surgery. 1 case of rectal perforation, which was managed by endoscopic treatment and conservative treatment. All cases did not appear haemorrhage. During a mean follow-up period of 22.6 months, local recurrences occurred in 1 case of stomach, and treated with second line ESD. No cases lymph node and distant metastasis were found.Conclusion ESD appears to be a feasible, safe and effective treatment for GI-NENs with strict endoscopic treatment indications.
