Comparison of the impact of laparoscopic and open surgery on immune function in colon cancer patients

VernacularTitle:结肠癌应用腹腔镜以及开腹手术治疗对机体免疫功能的影响比较
Author: Bo MO ; Juan MA ; Zhinan HAO ; Bing XU
Keywords: colon cancer; laparoscopy; open surgery; immune function
From: China Journal of Endoscopy 2016;22(6):24-26
CountryChina
Language:Chinese
Abstract: Objective To study the impact of laparoscopic radical resection and open radical resection on immune function in patients with colon cancer. Methods 110 cases received complete mesocolic excision surgery of the right colon cancer patients, according to the different surgical methods divided into observation group and control group, the observation group adopted laparoscopic surgery while the control group treated with open surgery, then compared the inflammatory stress response and related immunology index changes before and after operation. Results After op-eration, inflammatory stress indicators such as MCP-1, HMGB-1, Glucagon, BG in observation group were signifi-cantly better than that in control group. After operation, WBC, CRP, IL-6 index in the two groups were significantly improved. CRP, IL-6, CD4+, CD8+, NK cell index in observation group was significantly better than that in control group. There were significant differences between the two groups, < 0.05. Conclusion Laparoscopic CME surgery can help to relieve inflammatory stress response, and the immune function is less affected, it is worthy of promoting clinical application.