Phloroglucinol and Misoprostol for cervix pretreatment before diagnostic hysteroscopy:a meta-analysis of randomized controlled trials
10.3969/j.issn.1007-1989.2016.06.018
- VernacularTitle:间苯三酚与米索前列醇在宫腔镜术前促宫颈成熟效果比较的Meta分析
- Author:
Jingli SUN
;
Qing WANG
;
Shaofeng GAO
;
Ying ZHAO
;
Ying LI
;
Xiuxia WANG
;
Yingjun WANG
- Keywords:
Phloroglucinol;
Misoprostol;
hysteroscope;
randomized controlled trials;
meta-analysis
- From:
China Journal of Endoscopy
2016;22(6):72-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the efficiency and safety of Phloroglucinol and Misoprostol for cervix pretreat-ment before diagnostic hysteroscopy. Methods Trials were located through electronic searches of the PubMed, MED-LINE, Springer, CNKI, VIP, CBM, WanFang Data (from the date of establishment of the databases to June 2015). Bibliographies of the retrieved articles were also checked. Result A total of 18 trials involving 2 341 patients were included. The Meta-analysis showed: application of Phloroglucinol lenovo better open and dilate the cervix [O? =2.95, 95 % CI (1.96, 4.45), = 0.000]; To better clarity of the operative field [ O? = 9.50, 95 % CI (6.46, 13.98), = 0.000]; To better shorten the operation time [O? =-4.12, 95 % CI (-5.75,-2.49), =0.000];To bet-ter able to reduce the amount of intraoperative leakage [ O? =0.22, 95%CI (0.10, 0.49), = 0.0002]; and postop-erative adverse reactions should be significantly lower than Misoprostol [ O? = 0.01, 95 % CI (0.00, 0.04), =0.000]. The difference was statistically significant. Conclusions Phloroglucinol is more effective and safer than Miso-prostol in inducing proper cervical priming and may be the optimal choice for cervical pretreatment before diagnostic hysteroscopy.
