Clinical effect of endoscopic implantation of accurate and slow-release particles for advanced esophageal carcinoma
10.3969/j.issn.1007-1989.2016.09.007
- VernacularTitle:精准靶向缓释化疗粒子植入治疗进展期食管癌的临床研究
- Author:
Li WANG
;
Linyan LI
;
Dan HUANG
;
Dongmei DENG
;
Liming WEN
- Keywords:
esophageal carcinoma;
5-Fu;
implantation of accurate and slow-release particles
- From:
China Journal of Endoscopy
2016;22(9):30-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects by endoscopic implantation of accurate and slow-release particles for advanced esophageal carcinoma. Methods Under endoscopy, we dividing the whole focus into several layers by each 1.0 cm and implanting one slow-release particles (about 10 mg) in each point whose interval is 1.0 cm. One course of treatment includes three-time implantation and each treatment needs four weeks, by the way the details depend on the state of illness. In this research, all of patients complete the treatment smoothly. By comparing the patients’ situation before treatment, three-month treatment and six-month treatment, which include the remission of clinical symptom, the changing of focus area, the improvement of swallow function, untoward effect and life quality, et al. Results The results show several test indexes changed a lot. When treated for 3 months and 6 months, the levels of focus area and swallow difficulty classification were decreased significantly (P < 0.05) as compared with those before treatment; but the patients’ life quality didn’t have significant statistical difference (P > 0.05), by the way there isn’t individual difference appearing because of a little short of testing time and a few of samples. In addition, the WBC had a significant statistical difference between before treatment and three-month treatment (P < 0.05), and the ratio of complication didn’t have a significant change. Conclusions Endoscopic implantation of 5-Fu slow-release particles for the treatment of advanced esophageal carcinoma is a safety, high efficacy, low toxic and good tolerant palliative treatment.
