Impact of lung volume reduction surgery on inflammatory factors, pulmonary function and quality of life in patients with severe chronic obstructive pulmonary emphysema
10.3969/j.issn.1007-1989.2016.07.004
- VernacularTitle:电视胸腔镜下肺减容术对重度慢性阻塞性肺气肿患者炎性因子、肺功能及生活质量的影响
- Author:
Xiaojie ZHANG
;
Zhiming CHEN
;
Qiushi ZHANG
;
Shien HUANG
;
Min DENG
- Keywords:
lung volume reduction surgery;
video assisted thoracic surgery;
chronic obstructive pulmonary emphy﹣sema;
inflammatory factor;
pulmonary function
- From:
China Journal of Endoscopy
2016;22(7):14-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the impact of lung volume reduction surgery on inflammatory factors, pulmonary function and quality of life in patients with severe chronic obstructive pulmonary emphysema. Methods 57 cases patients with severe chronic obstructive pulmonary emphysema received lung volume reduction surgery from May 2009 to December 2013 were divided into observation group 32 cases and control group 25 cases, the control group were given open chest surgery, the observation group received video-assisted thoracoscopic surgery. Then compare the operation indicator, serum inflammatory factor content, pulmonary function and life quality score between the two groups. Results Operation indicators: Observation group: Intraoperative blood loss, thoracic drainage, hospital stay were significantly lower than that in control group (P< 0.05); Inflammatory factor: 3 d after surgery, observation group serum TNF-α, IL- 6, IL- 1 content were significantly lower than that in control group (P<0.05);Pulmonary function: 12 months after surgery, there were no statistical difference of FEV1, TLC, RV between two groups (P>0.05); SGRQ score: 12 weeks after the surgery, observation group respiratory symptoms, activity ability, disease im﹣pact, SGRQ total score were significantly lower than the control group (P< 0.05). Conclusion Video assisted tho﹣racic surgery helps to reduce surgical trauma, and alleviate inflammatory reaction, then improve the quality of life.
