Comparative study of laparoscopic and transabdominal radical hysterectomy's impact on the cellular immunity
10.3969/j.issn.1007-1989.2016.03.001
- VernacularTitle:腹腔镜与开腹宫颈癌根治术对机体细胞免疫影响的对比研究
- Author:
Xiangqun WEI
;
Chunxiu WU
;
Hao FENG
;
Wenliang LI
;
Yanhuan CHEN
- Keywords:
cellular immunity;
cervical cancer;
laparoscopic cervical cancer radical prostatectomy;
human leuko-cyte antigen-DR (HLA-DR);
T-cell subsets
- From:
China Journal of Endoscopy
2016;22(3):1-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the difference of impact on the cellular immunity between laparoscopic and transabdominal radical hysterectomy. Methods 60 patients with early cervical cancer (Ⅰa2~Ⅱa1), half of them were assigned to do abdominal radical hysterectomy (ARH) and the other half for laparoscopic radical hysterectomy (LRH). Adopt flow cytometry (FCM) detect peripheral blood T lymphocyte subsets, NK cells, CIK cells and T lymphocyte ac-tivation function on one day before surgery, one day, five days, and 28 days after the surgery separately. Compare the changes of immune status. Results After one day, the number of T lymphocyte subsets declined compared with preoperative one day(P <0.05). After five days, each index in LRH group was increased compared with postoperative one day, and the degree of decline is less than the ARH group ( P< 0.05), and recovered faster. After one day, the number of HLA-DR+CD3+in LRH group compared with the preoperative one day declined and HLA-DR+CD8+in-creased, and the degree of change is less than the ARH group, and recovered faster. Conclusions Immune function in patients after laparoscopic group was less changed, and recovered quickly, while the immune function were less inhibited, it may protect patients' immune function better.
