Photopic laryngoscope can reduce half effective concentration of Propofol for inhibiting intubation response
10.3969/j.issn.1007-1989.2016.03.002
- VernacularTitle:明视喉镜可降低一定瑞芬太尼浓度下异丙酚抑制插管反应的半数有效靶控浓度
- Author:
Wanwen HE
;
Aiting LIN
;
Rui GUO
;
Lixun WANG
;
Youli CHEN
- Keywords:
photopic laryngoscope;
Propofol;
intubation reaction;
half effective concentration
- From:
China Journal of Endoscopy
2016;22(3):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the EC50 of Propofol for inhibiting intubation response. Methods 80 cases un-derwent tracheal intubation general anesthesia, all patients were randomly divided into two groups. The general situ-ation between the two groups showed no significant difference. Except for Propofol, other anesthesia drugs infusion method and dosage were the same. Sequential determination the EC50 of Propofol which for inhibiting intubation re-sponse of each groups by up-and-down. Propofol target concentration of the first patient was set to 4 μg/ml, and ad-justed according to intubation stress response disappeared or not, concentration of two adjacent patients with ratio of 1.2. Results A group inhibited the cardiovascular responses of Propofol EC50 and 95%CI was 5.19 μg/ml (95%CI:4.88 ~ 5.50 μg/ml). B group inhibited the cardiovascular responses of Propofol EC50 and 95 %CI was 4.15μg/ml (95%CI:3.80~4.40μg/ml). The EC50 and 95% confidence interval of the B group were significantly lower than those of the A group ( P< 0.05). The MAP and HR at T2 were higher than that of T1 in each group ( P< 0.05), and the MAP and HR of observe group were lower than that of control group ( P< 0.05). The MAP and HR at T3 were lower than that of T1 in control group ( P< 0.05), but there were no significant deference in observe group ( P> 0.05).Conclusion The EC50 and 95% confidence interval of Propofol for inhibiting intubation response under photopic laryngoscopes was significant lower than those of under direct laryngoscopes, the circulation during period of induc-tion and intubation was more stable.
