Timing of Indomethacin suppositories for the prevention of post-ERCP pancreatitis in high risk groups
10.3969/j.issn.1007-1989.2016.03.005
- VernacularTitle:吲哚美辛栓预防高危人群发生内镜逆行胰胆管造影术后胰腺炎给药时机的前瞻性研究
- Author:
Yunyan LIU
;
Baijing DING
;
Mingkai CHEN
;
Zhongbao CAO
;
Sheng LI
;
Yong YANG
;
Chong LIU
;
Zhen CHENG
- Keywords:
endoscopic retrograde cholangiopancreatography;
post-ERCP pancreatitis;
C reactive protein;
inter-leukin 6;
tumor necrosis factor-α
- From:
China Journal of Endoscopy
2016;22(3):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective A prospective randomized controlled trial was carried out to explore the best time of In-domethacin suppositories administration for the prevention of post-ERCP pancreatitis in high-risk groups. Methods 81 patients were enrolled in the study finally. Patients were randomized into group A (100 mg rectal Indomethacin suppositories was administrated immediately after ERCP), group B (100 mg rectal Indomethacin suppositories was administrated half an hour after ERCP) and group C (ERCP alone group, which did not give Indomethacin supposito-ries). The level of serum amylase, urine amylase, serum CRP, serum IL-6, serum TNF-α were measured before, 3 h, 24 h and 48 h after ERCP, and the incidence of PEP and hyperamylasemia were analyzed. Results There was 1 case (4.00%) of PEP in group A, 2 cases (5.41%) of PEP in group B and 5 cases (26.31%) of PEP in group C;the incidences of PEP of group A and group B were significant lower than that in group C (P < 0.05). There was 1 case (4.00%) of hyperamylasemia in group A, 5 cases (13.51 %) of hyperamylasemia in group B and 6 cases (31.6 %) of hyperamylasemia in group C, and the incidences of hyperamylasemia of group A and group B were significant lower than that in group C ( P< 0.05). Conclusion Administration of 100 mg Indomethacin suppositories immediately or half an hour after ERCP can effectively reduce the incidence of PEP and hyperamylasemia.
