Radiotherapy induced gastroduodenal ulcer after concurrent chemoradiotherapy in pancreatic cancer
10.3969/j.issn.1007-1989.2016.02.011
- VernacularTitle:胰腺癌同步放化疗后放射性胃、十二指肠溃疡发生的临床研究
- Author:
Xiaopei GUO
;
Hualin WEI
;
Xiao CHEN
;
Xialu ZHANG
;
Jianhui LIU
;
Ping ZHOU
- Keywords:
pancreatic cancer;
chemoradiotherapy;
gastroduodenal;
ulcer
- From:
China Journal of Endoscopy
2016;22(2):46-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the endoscopic observation of pancreatic cancer radiotherapy induced gastro-duodenal radioactive injury, and investigate the influence of radiation-induced ulceration by concurrent chemoradio-therapy with S-1 (Tegafur Gimeracil Oteracil Potassium Capsule) and gemcitabine. Methods Self-comparative study of endoscopic performance were performed on patients received endoscopy before and after pancreatic cancer Chemoradiotherapy with S-1 or gemcitabine or radiotherapy only, from February 2010 to May 2015. Pearson chi-square test was used to analyze whether Concurrent Chemoradiotherapy groups and radiotherapy group are different in radiation-induced ulceration occurrence rate. Results The incidence of radiation-induced ulceration of radiother-apy group, S-1 group and gemcitabine group are 44.1 % (26/59), 50.0 % (10/20) and 46.7 % (7/15), respectively. Radiation-induced ulceration incidence was no statistical difference among the three groups. Conclusion From the angle of safety, patients can according to their self-condition for choosing S-1 or gemcitabine chemotherapy. Wether the concurrent chemoradiotherapy treatment was adopted or not, the occurrence rate of radiation-induced ulceration has no significant difference.
