Effects of Bivalirudin on ICAM-1 Level in Plasma of Patients Undergoing Percutaneous Coronary Intervention
- VernacularTitle:经皮冠状动脉介入术中应用比伐卢定对患者血浆细胞间黏附分子-1水平的影响观察
- Author:
Xiaxia FENG
;
Beide ZHU
;
Xiangdong XU
;
Hongsong LI
;
Fei WANG
;
Yinghua WANG
;
Yongjun MENG
- Keywords:
Bivalirud;
Heparin;
Percutaneous coronary intervention;
ICAM-1
- From:
China Pharmacist
2017;20(8):1391-1392,1419
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of domestic bivalirudin on plasma intercellular adhesion molecular-1 (ICAM-1) during percutaneous coronary intervention (PCI).Methods: Sixty PCI candidates were randomly divided into heparin group (n =30) and bivalirudin group (n =30).They were respectively treated with intravenous heparin and domestic bivalirudin as the anticoagulants during PCI.ICAM-1 in blood was measured before PCI and in 2h, 1d and 7d after PCI, respectively.Results: In heparin group, ICAM-1 level decreased significantly in 2 h after the intravenous injection when compared with that before the injection and that in bivalirudin group at the same time point (P＜0.05).No significant differences in ICAM-1 level were found on the 1st and 7th day after PCI in the two groups when compared with that before the administration (P＞0.05).Mild bleeding occurred in three patients receiving heparin and one patient receiving bivalirudin,but there was no significant difference after PCI.Conclusion: Compared with bivalivudin, heparin has a short inhibitory effect on the expression of ICAM-1 during PCI.It is beneficial to the patients with kidney disease or stroke during PCI.
