Changes and Clinical Significance of serum IL-18,IL-6 and CRP in patients with hypoxic ischemic encephalopathy
10.3969/j.issn.1673-4130.2017.13.026
- VernacularTitle:血清IL-6、IL-18及CRP水平在新生儿缺氧缺血性脑病中变化及意义
- Author:
Lichun ZHANG
;
Ping ZHUO
- Keywords:
hypoxic ischemic encephalopathy;
interleukin;
C-reactive protein
- From:
International Journal of Laboratory Medicine
2017;38(13):1798-1800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of changes of serum.IL-6,IL-18 and C-reactive protein(CRP) in patients with hypoxic ischemic encephalopathy (HIE).Methods Serum IL-6,IL-18 and CRP levels were measured by ELISA and immunity turbidimetry respectively in 100 patients with HIE and 100 health control.Results The HIE group serum IL-6,IL-18 and CRP levels were higher than the healthy control group,and Serum levels of IL-6,IL-18 and CRP increased when the clinical manifestation gradually increased.The CRP were positive correlation with serum levels of IL-6 and IL-18(r=0.663,0.725,all P<0.01).and the serum level of IL-6is positive correlation with IL-18(r=0.783,all P<0.01).Conclusion The serum IL-6,IL-18 and CRP may play an important role in the development process of HIE.Which were correlate to the severity of the disease and clinical change,measurements of their serum concentrations may help to predict these pathogenetic condition and prognosis criterion of the disease.
