The clinical study of Centaur CP detection of prostate specific antigen
10.3969/j.issn.1673-4130.2017.13.006
- VernacularTitle:CentaurCP检测前列腺特异性抗原的临床应用研究
- Author:
Ping ZHU
;
Wenjing ZHANG
;
Dehong LI
;
Fujia XIE
;
Chen CHAI
;
Yan LU
- Keywords:
prostate specific antigen;
prostate cancer;
benign prostatic hyperplasia;
sensitivity;
specificity
- From:
International Journal of Laboratory Medicine
2017;38(13):1743-1745,1748
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of prostate specific antigen (PSA),compound prostate specific antigen(cPSA),and cPSA / tPSA ratio in prostatic cancer(PCa).Methods Two hundred nineteen people,aged 62-68,were divided into three groups according to the clinical diagnosis,including PCa group(n=73),benign prostatic hyperplasia(BPH) group(n=76) and control group(n=70) composed of healthy people.The various indicators,including tPSA,cPSA and cPSA/tPSA were measured by Advia Centaur CP chemiluminescent analyzer.Results tPSA,cPSA and c/t significantly increased in PCa group compared with those in BPH or control group (P<0.05).ROC analysis indicated that if the tPSA cut-off values was19.89 μg/L,the sensitivity,specificity,the area under the curve (AUC) and Youden index would be 94.5%,97.9%,0.96 and 0.924 respectively.If the cut-off value of cPSA was 13.14 μg/L,the sensitivity,specificity,the area under the curve(AUC) and Youden index would be 95.9%,91.8%,0.98 and 0.877 respectively.The chi-square test showed that there is no correlation between tPSA,cPSA and pathology diagnosis(χ2=102.036、151.409,P<0.05).Conclusion PCa or PCa treatment relapse should be highly suspected when the concentration of tPSA or cPSA in patients reached 19.89 μg/L and 13.14 μg/L,the patients should be reminded for treatment timely.
