Relationship between serum TNF-α and IL-6 levels and respiratory function in patients with chronic obstructive pulmonary disease
10.3969/j.issn.1673-4130.2017.13.020
- VernacularTitle:血清中IL-6、TNF-α与慢性阻塞性肺疾病患者病情分级、呼吸功能的关系
- Author:
Jing REN
- Keywords:
chronic obstructive pulmonary disease;
inflammatory factor;
pulmonary function;
condition
- From:
International Journal of Laboratory Medicine
2017;38(13):1781-1783
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum TNF-α and IL-6 levels and respiratory function in patients with chronic obstructive pulmonary diseases.Methods 50 cases in our hospital diagnosed as chronic obstructive pulmonary disease from September 2015 to September 2016 were selected as the observation group,and 40 cases of healthy people were enrolled as the control group,serum IL-6,TNF-α were detected by ELISA in those people,correlation analysis was used to explore the relation ship between serum inflammatory factors,grading of disease and respiratory function in patients with chronic obstructive pulmonary disease(COPD).Results In the observation group TNF-α[(4.27±0.34)μg/L],IL-6[(21.54±3.67)ng/L] were significantly higher than those in healthy control group[(1.36±0.29)μg/L,(10.27±1.36)ng/L],the difference were statistically significant(P<0.05).COPD patients in different GOLD stage differed in the serum contents of TNF-α,IL-6 and symptom score(P<0.05).The serum contents of TNF-α,IL-6 and symptom score were higher when the GOLD stage got higher.TNF-α,IL-6 was positively correlated with symptom score,lung function,GOLD classification(P<0.05).Conclusion Serum levels of TNF-α,IL-6 and COPD are positively correlated with the patient′s condition,and positive correlation with pulmonary function.
