Serological diagnosis of hepatocellular carcinoma: challenges and opportunities
10.3969/j.issn.1001-5256.2017.07.011
- VernacularTitle:肝细胞癌的血清学诊断——挑战与希望同在
- Author:
Fengmin LU
- Keywords:
carcinoma,hepatocellular;
liver cirrhosis;
alpha-fetoproteins;
alpha-fetoprotein-L3;
des-gamma-carboxynprothrombin;
Golgi protein 73
- From:
Journal of Clinical Hepatology
2017;33(7):1262-1265
- CountryChina
- Language:Chinese
-
Abstract:
Serological markers have the features of noninvasiveness and simple operation and thus have become a research hotspot in the diagnosis of hepatocellular carcinoma.This article briefly introduces the role of the conventional serological marker alpha-fetoprotein (AFP) in assisting the diagnosis and predicting the prognosis of HBV-related liver cancer, as well as the clinical value of new markers such as alpha-fetoprotein-L3 and abnormal prothrombin/des-γ-carboxy prothrombin.Based on literature review, the possibility of serum Golgi protein 73 used for laboratory auxiliary diagnosis of hepatocellular carcinoma has been denied.The results of the author′s experiment suggest that serum GP73 measurement can be used as a laboratory diagnostic index for progressive liver fibrosis and liver cirrhosis.
